Ranked by reported Q1 2026 13F market value
Share of total reported institutional value in XERS held by the largest 10 / 25 filers.
| # | Institution | Shares Held | Market Value | QoQ Change | Ownership % | % of Fund |
|---|---|---|---|---|---|---|
| 1 | BlackRock, Inc. | 12.9M | $75.1M | +2.4% | 7.499% | 0.00% |
| 2 | D. E. Shaw & Co., Inc. | 7.8M | $45.2M | +2.8% | 4.511% | 0.04% |
| 3 | STATE STREET CORP | 4.7M | $27.0M | +13.2% | 2.698% | 0.00% |
| 4 | GEODE CAPITAL MANAGEMENT, LLC | 4.3M | $24.9M | +0.3% | 2.485% | 0.00% |
| 5 | Qube Research & Technologies Ltd | 4.1M | $23.9M | +17.6% | 2.383% | 0.03% |
| 6 | Rosalind Advisors, Inc. | 3.2M | $18.7M | +53.0% | 1.872% | 7.68% |
| 7 | Nuveen, LLC | 2.9M | $16.9M | +3.9% | 1.689% | 0.00% |
| 8 | MORGAN STANLEY | 2.6M | $14.9M | -5.0% | 1.490% | 0.00% |
| 9 | MILLENNIUM MANAGEMENT LLC | 2.3M | $13.1M | +163.8% | 1.313% | 0.01% |
| 10 | WELLINGTON MANAGEMENT GROUP LLP | 2.2M | $12.6M | -5.0% | 1.258% | 0.00% |
| 11 | TWO SIGMA INVESTMENTS, LP | 1.9M | $11.2M | +11.1% | 1.115% | 0.01% |
| 12 | ARMISTICE CAPITAL, LLC | 1.9M | $11.1M | — | 1.106% | 0.33% |
| 13 | Legal & General Group Plc | 1.9M | $11.1M | +36.7% | 1.105% | 0.00% |
| 14 | Parkman Healthcare Partners LLC | 1.7M | $10.0M | +1.8% | 0.997% | 1.04% |
| 15 | UBS Group AG | 1.6M | $9.5M | +173.6% | 0.954% | 0.00% |
| 16 | GOLDMAN SACHS GROUP INC | 1.6M | $9.4M | +2.9% | 0.935% | 0.00% |
| 17 | NORTHERN TRUST CORP | 1.4M | $8.4M | +4.2% | 0.837% | 0.00% |
| 18 | Voss Capital, LLC | 1.4M | $8.2M | +257.5% | 0.816% | 0.46% |
| 19 | AQR CAPITAL MANAGEMENT LLC | 1.4M | $8.1M | +45.6% | 0.808% | 0.00% |
| 20 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1.4M | $7.9M | -3.1% | 0.788% | 0.00% |
| 21 | CenterBook Partners LP | 1.2M | $7.2M | -10.3% | 0.723% | 0.39% |
| 22 | KENNEDY CAPITAL MANAGEMENT, INC. | 1.2M | $7.2M | +2.2% | 0.719% | 0.15% |
| 23 | Knott David M Jr | 1.1M | $6.1M | +9.3% | 0.614% | 3.66% |
| 24 | Caption Management, LLC | 1.1M | $6.1M | — | 0.609% | 0.06% |
| 25 | Ishara Investments LP | 1.0M | $5.9M | +28.1% | 0.594% | 5.63% |
denotes a marquee investor (Buffett, Burry, ARK, Tiger Global, Pershing Square, Baupost and other widely-followed managers). “% of Fund” shows how much of that investor’s total 13F portfolio is invested in XERS — a direct measure of their conviction.
Filings activity in XERS during Q1 2026, grouped by how each filer changed its position.
8 quarters of 13F filings · Δ columns show change vs prior quarter
| Quarter | Inst. Holders | Δ Holders | Ownership % | Δ Ownership | Total 13F Value | Δ Value |
|---|---|---|---|---|---|---|
| Q1 2026 | 223 | +0.0% | 45.43% | 20.42 pp | $533M | 31% |
| Q4 2025 | 223 | 2.2% | 65.85% | 0.19 pp | $772M | 0.3% |
| Q3 2025 | 228 | +13% | 66.04% | +30.72 pp | $774M | +87% |
| Q2 2025 | 201 | +2.0% | 35.32% | 3.62 pp | $414M | 9.3% |
| Q1 2025 | 197 | +23% | 38.94% | +20.70 pp | $456M | +113% |
| Q4 2024 | 160 | +13% | 18.24% | +3.33 pp | $214M | +22% |
| Q3 2024 | 142 | +5.2% | 14.91% | +3.76 pp | $175M | +34% |
| Q2 2024 | 135 | — | 11.15% | — | $131M | — |
Source: SEC 13F institutional filings. Ownership % requires market cap data and will show once linked. Δ columns compare to the immediately prior filed quarter.
Quick answers to the most common questions about buying XERS stock.
Based on Q1 2026 13F filings, institutional ownership of Xeris Biopharma Holdings, Inc. stands at 45.4%, held across 223 reporting institutions.
BlackRock, Inc. is the largest reported institutional holder of XERS, with approximately 12,945,785 shares worth $0.08B as of Q1 2026.
Yes — 2 widely-followed marquee investors appear among the top 25 institutional holders of XERS, including MILLENNIUM MANAGEMENT LLC, TWO SIGMA INVESTMENTS, LP.
Our composite Smart Money Score for XERS is 45 out of 100 (Neutral). It combines net institutional buying activity, ownership shift, marquee investor presence, and holder-count growth.
38 institutions opened new positions in XERS during Q1 2026, while 38 fully exited. 42 added to existing positions and 141 trimmed.
XERS institutional ownership fell by 20.42 percentage points quarter-over-quarter, with a net change of +0 holders.
The top 10 institutions account for 51.1% of all reported 13F value in XERS, and the top 25 account for 75.1%.
All data is sourced from SEC Form 13F filings, which institutional investment managers with at least $100M in assets are required to file each quarter. We process every 13F filing from EDGAR and recompute the aggregates after each cycle. Insider transactions are sourced from Form 4 filings.
Xeris Biopharma Holdings, Inc. (XERS) Institutional Ownership