Last 46 quarters of trend data · Healthcare · Biotechnology
Quarterly valuation ratios — annualised for comparability. YoY Δ shows same-quarter-prior-year change.
| Metric | TTM | Q1 '26 | Q4 '25 | Q3 '25 | Q2 '25 | Q1 '25 | Q4 '24 | Q3 '24 | Q2 '24 | Q1 '24 | Q4 '23 | Q3 '23 | Q2 '23 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| P/E Ratio → | -68.07 | — | — | — | — | — | — | — | — | — | — | — | — |
| — | — | — | — | — | — | — | — | — | — | — | — | — | |
| P/S Ratio | 20.19 | 11.31 | 11.80 | 8.88 | 8.60 | 11.73 | 8.65 | 10.32 | 10.98 | 12.61 | 13.17 | 14.24 | 16.80 |
| — | -3.6% | +36.4% | -14.0% | -21.7% | -6.9% | -34.3% | -27.5% | -34.6% | +77.7% | -61.7% | -48.4% | -60.4% | |
| P/B Ratio | 141.14 | 158.53 | 104.73 | 82.40 | 70.63 | 107.13 | 72.04 | 46.57 | 37.23 | 26.26 | 19.72 | 12.22 | 11.26 |
| — | +48.0% | +45.4% | +76.9% | +89.7% | +308.0% | +265.2% | +281.2% | +230.8% | +9.4% | -35.5% | +3.3% | -88.6% | |
| P/FCF | — | — | — | 1537.24 | — | — | — | — | — | — | — | — | — |
| — | — | — | — | — | — | — | — | — | — | — | — | — | |
| EV / EBITDA | — | — | — | — | — | — | — | — | — | — | — | — | — |
| — | — | — | — | — | — | — | — | — | — | — | — | — | |
| EV / EBIT | — | — | — | — | — | — | — | — | — | — | — | — | — |
| — | — | — | — | — | — | — | — | — | — | — | — | — |
Quarterly margins and returns. Watch for margin compression across consecutive quarters.
Axsome Therapeutics, Inc.'s operating margin was -33.1% in Q1 2026, down 18.1 pp QoQ and up 13.8 pp YoY. The trailing four-quarter average of -24.9% exceeds the current quarter, suggesting the latest result may reflect seasonal weakness or a one-off headwind.
| Metric | TTM | Q1 '26 | Q4 '25 | Q3 '25 | Q2 '25 | Q1 '25 | Q4 '24 | Q3 '24 | Q2 '24 | Q1 '24 | Q4 '23 | Q3 '23 | Q2 '23 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Gross Margin | 92.6% | 92.3% | 93.7% | 93.0% | 91.0% | 91.9% | 91.1% | 91.9% | 90.8% | 91.6% | 89.7% | 88.7% | 90.2% |
| — | +0.4% | +2.8% | +1.2% | +0.3% | +0.4% | +1.6% | +3.7% | +0.7% | -0.4% | -1.0% | +0.1% | +1.5% | |
| Operating Margin | -26.5% | -33.1% | -15.0% | -27.0% | -24.5% | -46.9% | -61.1% | -59.8% | -89.5% | -89.7% | -137.4% | -107.5% | -139.3% |
| — | +29.4% | +75.4% | +54.9% | +72.7% | +47.7% | +55.5% | +44.4% | +35.7% | -1231.0% | +44.1% | +57.3% | +68.6% | |
| Net Margin | -28.7% | -33.8% | -14.6% | -27.6% | -32.0% | -48.9% | -63.1% | -61.7% | -91.0% | -91.1% | -137.9% | -107.6% | -143.8% |
| — | +31.0% | +76.9% | +55.2% | +64.9% | +46.3% | +54.3% | +42.7% | +36.7% | -668.4% | +45.1% | +59.6% | +69.4% |
| Metric | TTM | Q1 '26 | Q4 '25 | Q3 '25 | Q2 '25 | Q1 '25 | Q4 '24 | Q3 '24 | Q2 '24 | Q1 '24 | Q4 '23 | Q3 '23 | Q2 '23 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ROE | -252.1% | -90.3% | -35.3% | -64.3% | -76.0% | -107.8% | -99.9% | -66.0% | -64.3% | -40.8% | -42.8% | -22.7% | -34.4% |
| — | +16.2% | +64.7% | +2.5% | -18.2% | -164.2% | -133.3% | -190.9% | -86.9% | -302.6% | +6.6% | +56.3% | +87.6% | |
| ROA | -29.1% | -9.2% | -4.2% | -7.2% | -7.8% | -10.2% | -13.3% | -11.6% | -14.5% | -12.1% | -16.6% | -10.3% | -13.4% |
| — | +9.8% | +68.3% | +38.0% | +46.5% | +15.4% | +20.1% | -13.5% | -8.1% | -287.3% | +9.2% | +40.5% | +56.4% | |
| ROIC | -1906.7% | — | -331.6% | — | — | — | — | — | — | — | -496.8% | -143.5% | -247.5% |
| — | — | — | — | — | — | — | — | — | — | -52.4% | -35.7% | +31.6% |
Quarterly solvency trend — watch for debt spikes or covenant pressure.
The current ratio has weakened 31.4% YoY to 1.39x, tightening the short-term liquidity position.
| Metric | TTM | Q1 '26 | Q4 '25 | Q3 '25 | Q2 '25 | Q1 '25 | Q4 '24 | Q3 '24 | Q2 '24 | Q1 '24 | Q4 '23 | Q3 '23 | Q2 '23 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Debt / Equity | 2.73 | 3.97 | 2.73 | 2.96 | 2.97 | 3.97 | 3.38 | 2.07 | 1.86 | 1.32 | 0.98 | 0.69 | 0.66 |
| — | -0.0% | -19.2% | +43.2% | +59.5% | +201.9% | +246.8% | +200.6% | +181.5% | -0.5% | +12.9% | +14.9% | -89.3% | |
| Debt / EBITDA | — | — | — | — | — | — | — | — | — | — | — | — | — |
| — | — | — | — | — | — | — | — | — | — | — | — | — | |
| Current Ratio | 1.55 | 1.39 | 1.55 | 1.57 | 1.57 | 2.03 | 2.11 | 2.44 | 2.48 | 3.20 | 3.63 | 4.46 | 4.52 |
| — | -31.4% | -26.2% | -35.7% | -36.8% | -36.6% | -42.0% | -45.3% | -45.1% | +5.7% | +42.8% | +6.6% | +85.1% | |
| Quick Ratio | 1.48 | 1.32 | 1.48 | 1.50 | 1.51 | 1.96 | 2.04 | 2.37 | 2.40 | 3.09 | 3.52 | 4.38 | 4.44 |
| — | -32.7% | -27.4% | -36.6% | -36.9% | -36.5% | -42.1% | -45.9% | -45.9% | +4.8% | +41.0% | +5.4% | +101.8% | |
| Interest Coverage | -27.02 | -53.47 | -23.00 | -41.17 | -24.44 | -23.44 | -32.86 | -31.66 | -60.08 | -62.18 | -139.99 | -82.06 | -23.83 |
| — | — | — | — | — | — | — | — | — | — | — | — | — |
Includes 30+ ratios · 46 years · Updated daily
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Quick answers to the most common questions about buying AXSM stock.
Axsome Therapeutics, Inc.'s current P/E is -68.1x. Quarterly P/E ratios can vary due to seasonal revenue patterns and one-time charges.
Axsome Therapeutics, Inc.'s current operating margin is -26.5%. Margins have been compressing over recent quarters. Quarterly margins are particularly useful for identifying trend inflections that annual data smooths over.
Quarterly financial ratios reveal short-term trend shifts — margin compression, debt spikes, or valuation re-ratings — that annual figures smooth over. They're essential for active investors tracking Axsome Therapeutics, Inc.'s business trajectory between earnings reports.