Ranked by reported Q2 2026 13F market value
Share of total reported institutional value in KPTI held by the largest 10 / 25 filers.
| # | Institution | Shares Held | Market Value | QoQ Change | Ownership % | % of Fund |
|---|---|---|---|---|---|---|
| 1 | RA CAPITAL MANAGEMENT, L.P. | 1.9M | $18.7M | 0.0% | 8.460% | 0.16% |
| 2 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 1.5M | $14.9M | -15.8% | 6.713% | 0.02% |
| 3 | ACORN CAPITAL ADVISORS, LLC | 1.5M | $14.8M | +427.4% | 6.699% | 4.05% |
| 4 | GOLDMAN SACHS GROUP INC | 1.4M | $13.9M | +50.3% | 6.286% | 0.00% |
| 5 | BlackRock, Inc. | 1.4M | $13.9M | +479.3% | 6.260% | 0.00% |
| 6 | VANGUARD CAPITAL MANAGEMENT LLC | 959K | $9.4M | +29.6% | 4.231% | 0.00% |
| 7 | Catalio Capital Management, LP | 941K | $9.2M | +4.8% | 4.152% | 1.73% |
| 8 | Avidity Partners Management LP | 924K | $9.0M | +99.4% | 4.079% | 1.45% |
| 9 | TWO SIGMA INVESTMENTS, LP | 695K | $6.8M | +359.7% | 3.068% | 0.00% |
| 10 | Kalehua Capital Management LLC | 686K | $6.7M | — | 3.025% | 2.14% |
| 11 | NEA Management Company, LLC | 577K | $5.6M | — | 2.545% | 0.35% |
| 12 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 546K | $5.3M | -58.5% | 2.408% | 0.00% |
| 13 | GEODE CAPITAL MANAGEMENT, LLC | 531K | $5.2M | +157.7% | 2.344% | 0.00% |
| 14 | Ghisallo Capital Management LLC | 500K | $4.9M | — | 2.206% | 0.10% |
| 15 | Soleus Capital Management, L.P. | 440K | $4.3M | 0.0% | 1.942% | 0.15% |
| 16 | Caption Management, LLC | 378K | $3.7M | -68.0% | 1.669% | 0.02% |
| 17 | UBS Group AG | 354K | $3.5M | +82.2% | 1.560% | 0.00% |
| 18 | MILLENNIUM MANAGEMENT LLC | 342K | $3.3M | -33.2% | 1.508% | 0.00% |
| 19 | STATE STREET CORP | 326K | $3.2M | +303.7% | 1.438% | 0.00% |
| 20 | Affinity Asset Advisors, LLC | 313K | $3.1M | -37.5% | 1.379% | 0.14% |
| 21 | Brevan Howard Capital Management LP | 310K | $3.0M | +45.9% | 1.367% | 0.02% |
| 22 | Boxer Capital Management, LLC | 303K | $3.0M | 0.0% | 1.335% | 0.22% |
| 23 | DAVIDSON KEMPNER CAPITAL MANAGEMENT LP | 300K | $2.9M | 0.0% | 1.324% | 0.03% |
| 24 | SILVERARC CAPITAL MANAGEMENT, LLC | 297K | $2.9M | — | 1.313% | 0.30% |
| 25 | Eversept Partners, LP | 276K | $2.7M | -7.9% | 1.219% | 0.14% |
denotes a marquee investor (Buffett, Burry, ARK, Tiger Global, Pershing Square, Baupost and other widely-followed managers). “% of Fund” shows how much of that investor’s total 13F portfolio is invested in KPTI — a direct measure of their conviction.
Filings activity in KPTI during Q2 2026, grouped by how each filer changed its position.
6 quarters of 13F filings · Δ columns show change vs prior quarter
| Quarter | Inst. Holders | Δ Holders | Ownership % | Δ Ownership | Total 13F Value | Δ Value |
|---|---|---|---|---|---|---|
| Q2 2026 | 99 | +19% | 100.57% | 11.62 pp | $211M | +62% |
| Q1 2026 | 83 | +17% | 112.19% | +60.65 pp | $130M | +103% |
| Q4 2025 | 71 | +34% | 51.54% | +36.28 pp | $64M | +273% |
| Q3 2025 | 53 | +6.0% | 15.26% | 4.16 pp | $17M | +13% |
| Q2 2025 | 50 | +6.4% | 19.42% | +4.67 pp | $15M | +22% |
| Q1 2025 | 47 | — | 14.75% | — | $12M | — |
Source: SEC 13F institutional filings. Ownership % requires market cap data and will show once linked. Δ columns compare to the immediately prior filed quarter.
Quick answers to the most common questions about buying KPTI stock.
Based on Q2 2026 13F filings, institutional ownership of Karyopharm Therapeutics Inc. stands at 100.6%, held across 99 reporting institutions.
RA CAPITAL MANAGEMENT, L.P. is the largest reported institutional holder of KPTI, with approximately 1,917,354 shares worth $0.02B as of Q2 2026.
Yes — 3 widely-followed marquee investors appear among the top 25 institutional holders of KPTI, including TWO SIGMA INVESTMENTS, LP, SUSQUEHANNA INTERNATIONAL GROUP, LLP, MILLENNIUM MANAGEMENT LLC.
Our composite Smart Money Score for KPTI is 56 out of 100 (Neutral). It combines net institutional buying activity, ownership shift, marquee investor presence, and holder-count growth.
33 institutions opened new positions in KPTI during Q2 2026, while 17 fully exited. 58 added to existing positions and 8 trimmed.
KPTI institutional ownership fell by 11.62 percentage points quarter-over-quarter, with a net change of +16 holders.
The top 10 institutions account for 55.6% of all reported 13F value in KPTI, and the top 25 account for 82.5%.
All data is sourced from SEC Form 13F filings, which institutional investment managers with at least $100M in assets are required to file each quarter. We process every 13F filing from EDGAR and recompute the aggregates after each cycle. Insider transactions are sourced from Form 4 filings.
Karyopharm Therapeutics Inc. (KPTI) Institutional Ownership