Ranked by reported Q1 2026 13F market value
Share of total reported institutional value in KPTI held by the largest 10 / 25 filers.
| # | Institution | Shares Held | Market Value | QoQ Change | Ownership % | % of Fund |
|---|---|---|---|---|---|---|
| 1 | Ikarian Capital, LLC | 2.6M | $14.3M | +372.6% | 30.143% | 1.52% |
| 2 | COMMODORE CAPITAL LP | 1.9M | $10.9M | β | 22.841% | 0.63% |
| 3 | RA CAPITAL MANAGEMENT, L.P. | 1.9M | $10.7M | β | 22.459% | 0.11% |
| 4 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 1.8M | $10.1M | +328.7% | 21.158% | 0.02% |
| 5 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 1.3M | $7.3M | +57.5% | 15.404% | 0.00% |
| 6 | GOLDMAN SACHS GROUP INC | 948K | $5.3M | β | 11.099% | 0.00% |
| 7 | Catalio Capital Management, LP | 898K | $5.0M | +527.8% | 10.515% | 1.04% |
| 8 | BOOTHBAY FUND MANAGEMENT, LLC | 750K | $4.2M | +418.9% | 8.790% | 0.11% |
| 9 | VANGUARD CAPITAL MANAGEMENT LLC | 740K | $4.1M | β | 8.665% | 0.00% |
| 10 | Avidity Partners Management LP | 464K | $3.9M | +244.6% | 5.432% | 0.87% |
| 11 | Affinity Asset Advisors, LLC | 500K | $2.8M | -43.8% | 5.857% | 0.16% |
| 12 | Soleus Capital Management, L.P. | 440K | $2.5M | 0.0% | 5.154% | 0.10% |
| 13 | ADAR1 Capital Management, LLC | 342K | $1.9M | +583.9% | 4.005% | 0.12% |
| 14 | Boxer Capital Management, LLC | 303K | $1.7M | +19.8% | 3.544% | 0.22% |
| 15 | DAVIDSON KEMPNER CAPITAL MANAGEMENT LP | 300K | $1.7M | -3.2% | 3.514% | 0.04% |
| 16 | Eversept Partners, LP | 300K | $1.7M | β | 3.514% | 0.11% |
| 17 | ACORN CAPITAL ADVISORS, LLC | 288K | $1.6M | β | 3.371% | 0.46% |
| 18 | Jump Financial, LLC | 262K | $1.5M | +387.1% | 3.071% | 0.02% |
| 19 | Trexquant Investment LP | 258K | $1.4M | +518.0% | 3.021% | 0.01% |
| 20 | BlackRock, Inc. | 245K | $1.4M | -1.1% | 2.869% | 0.00% |
| 21 | Brevan Howard Capital Management LP | 212K | $1.2M | β | 2.488% | 0.01% |
| 22 | GEODE CAPITAL MANAGEMENT, LLC | 206K | $1.1M | +9.8% | 2.414% | 0.00% |
| 23 | UBS Group AG | 194K | $1.1M | +119.3% | 2.273% | 0.00% |
| 24 | GROUP ONE TRADING, L.P. | 192K | $1.1M | +87.0% | 2.243% | 0.04% |
| 25 | SILVERBACK ASSET MANAGEMENT LLC | 165K | $919K | +312.5% | 1.933% | 0.19% |
denotes a marquee investor (Buffett, Burry, ARK, Tiger Global, Pershing Square, Baupost and other widely-followed managers). β% of Fundβ shows how much of that investorβs total 13F portfolio is invested in KPTI β a direct measure of their conviction.
Filings activity in KPTI during Q1 2026, grouped by how each filer changed its position.
5 quarters of 13F filings Β· Ξ columns show change vs prior quarter
| Quarter | Inst. Holders | Ξ Holders | Ownership % | Ξ Ownership | Total 13F Value | Ξ Value |
|---|---|---|---|---|---|---|
| Q1 2026 | 72 | +4.3% | 132.98% | +55.22 pp | $108M | +71% |
| Q4 2025 | 69 | +38% | 77.76% | +58.70 pp | $63M | +308% |
| Q3 2025 | 50 | +0.0% | 19.06% | +0.28 pp | $15M | +1.5% |
| Q2 2025 | 50 | +6.4% | 18.78% | +3.37 pp | $15M | +22% |
| Q1 2025 | 47 | β | 15.41% | β | $12M | β |
Source: SEC 13F institutional filings. Ownership % requires market cap data and will show once linked. Ξ columns compare to the immediately prior filed quarter.
Quick answers to the most common questions about buying KPTI stock.
Based on Q1 2026 13F filings, institutional ownership of Karyopharm Therapeutics Inc. stands at 133.0%, held across 72 reporting institutions.
Ikarian Capital, LLC is the largest reported institutional holder of KPTI, with approximately 2,573,435 shares worth $0.01B as of Q1 2026.
Yes β 1 widely-followed marquee investor appear among the top 25 institutional holders of KPTI, including SUSQUEHANNA INTERNATIONAL GROUP, LLP.
Our composite Smart Money Score for KPTI is 60 out of 100 (Bullish). It combines net institutional buying activity, ownership shift, marquee investor presence, and holder-count growth.
22 institutions opened new positions in KPTI during Q1 2026, while 19 fully exited. 24 added to existing positions and 26 trimmed.
KPTI institutional ownership rose by 55.22 percentage points quarter-over-quarter, with a net change of +3 holders.
The top 10 institutions account for 70.2% of all reported 13F value in KPTI, and the top 25 account for 91.9%.
All data is sourced from SEC Form 13F filings, which institutional investment managers with at least $100M in assets are required to file each quarter. We process every 13F filing from EDGAR and recompute the aggregates after each cycle. Insider transactions are sourced from Form 4 filings.
Karyopharm Therapeutics Inc. (KPTI) Institutional Ownership