Septerna, Inc. (SEPN) Earnings History
Annual and quarterly earnings data from 2022 to 2025
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SEPN EPS Growth (CAGR)
Compound annual growth rate of diluted earnings per share
CAGR (Compound Annual Growth Rate) shows the annualized growth rate of EPS over the specified period. A higher CAGR indicates stronger earnings momentum.
SEPN Profitability Analysis
Margin trends over time
| Year | Gross Margin | Operating Margin | Net Margin |
|---|---|---|---|
| 2025 | 0.0% | -148.6% | -106.4% |
| 2024 | 100.0% | -7518.4% | -6678.9% |
| 2023 | 100.0% | 1374.2% | 2768.2% |
| 2022 | - | - | - |
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Septerna, Inc. (SEPN) Earnings Overview
As of May 8, 2026, Septerna, Inc. (SEPN) reported trailing twelve-month net income of -$49M, reflecting +84.8% year-over-year growth. The company earned $-1.10 per diluted share over the past four quarters, with a net profit margin of -106.4%.
Looking at the long-term picture, SEPN's historical earnings data spans multiple years. The company achieved its highest annual net income of $4M in fiscal 2023.
Septerna, Inc. is currently reporting a net loss, though operating performance should be evaluated in the context of growth investments and industry dynamics View revenue history →
Compared to peers including KYMR (-$315M net income, -794.4% margin), RXRX (-$560M net income, -863.4% margin), VKTX (-$472M net income), SEPN has outperformed on profitability metrics. Compare SEPN vs KYMR →
SEPN Earnings vs Peers
Earnings metrics vs comparable public companies
SEPN Historical Earnings Data (2022–2025)
4 years| Fiscal Year | Net Income | YoY % | Operating Income | EPS (Diluted) | Net Margin | Op. Margin |
|---|---|---|---|---|---|---|
| 2025 | -$49M | +31.9% | -$68M | $-1.10 | -106.4% | -148.6% |
| 2024 | -$72M | -1817.7% | -$81M | $-7.26 | -6678.9% | -7518.4% |
| 2023 | $4M | +115.1% | $2M | $0.03 | 2768.2% | 1374.2% |
| 2022 | -$28M | - | -$28M | $-1.42 | - | - |
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Start ComparisonSEPN — Frequently Asked Questions
Quick answers to the most common questions about buying SEPN stock.
Is SEPN growing earnings?
SEPN EPS is $-1.10, with earnings growth accelerating to +84.8%. This exceeds the 5-year CAGR of N/A. TTM net income reached $-49M.
What are SEPN's profit margins?
Septerna, Inc. net margin is -106.4%, with operating margin at -148.6%. Below-average margins reflect competitive or cost pressures.
How consistent are SEPN's earnings?
SEPN earnings data spans 2022-2025. The accelerating earnings trend is +84.8% YoY. Historical data enables comparison across business cycles.