Ranked by reported Q1 2026 13F market value
Share of total reported institutional value in SEPN held by the largest 10 / 25 filers.
| # | Institution | Shares Held | Market Value | QoQ Change | Ownership % | % of Fund |
|---|---|---|---|---|---|---|
| 1 | RA CAPITAL MANAGEMENT, L.P. | 7.0M | $168.1M | 0.0% | 15.520% | 1.78% |
| 2 | TRV GP V, LLC | 6.2M | $149.4M | 0.0% | 13.789% | 37.25% |
| 3 | DRIEHAUS CAPITAL MANAGEMENT LLC | 4.4M | $105.6M | -8.6% | 9.752% | 0.78% |
| 4 | TRV GP VI, LLC | 4.2M | $101.2M | 0.0% | 9.344% | 74.64% |
| 5 | Samsara BioCapital, LLC | 3.1M | $75.7M | 0.0% | 6.986% | 7.35% |
| 6 | GOLDMAN SACHS GROUP INC | 2.9M | $69.8M | +7.0% | 6.448% | 0.01% |
| 7 | Siren, L.L.C. | 2.0M | $48.1M | 0.0% | 4.437% | 1.33% |
| 8 | BlackRock, Inc. | 1.8M | $43.8M | +1.2% | 4.043% | 0.00% |
| 9 | BVF INC/IL | 1.4M | $32.5M | -21.4% | 3.002% | 1.04% |
| 10 | Avoro Capital Advisors LLC | 1.3M | $32.1M | 0.0% | 2.967% | 0.33% |
| 11 | VANGUARD CAPITAL MANAGEMENT LLC | 1.2M | $28.8M | β | 2.655% | 0.00% |
| 12 | ADAR1 Capital Management, LLC | 1.1M | $26.2M | -5.9% | 2.418% | 1.64% |
| 13 | PRIMECAP MANAGEMENT CO/CA/ | 1.0M | $25.2M | +92.1% | 2.327% | 0.02% |
| 14 | JANUS HENDERSON GROUP PLC | 891K | $21.3M | β | 1.976% | 0.01% |
| 15 | First Light Asset Management, LLC | 733K | $17.6M | +18.1% | 1.626% | 1.58% |
| 16 | GEODE CAPITAL MANAGEMENT, LLC | 645K | $15.5M | +12.6% | 1.431% | 0.00% |
| 17 | STATE STREET CORP | 631K | $15.2M | +16.9% | 1.401% | 0.00% |
| 18 | Casdin Capital, LLC | 553K | $13.3M | 0.0% | 1.227% | 1.01% |
| 19 | VR Adviser, LLC | 506K | $12.2M | -17.2% | 1.123% | 0.45% |
| 20 | Catalio Capital Management, LP | 294K | $7.1M | 0.0% | 0.653% | 1.48% |
| 21 | Soleus Capital Management, L.P. | 275K | $6.6M | -28.3% | 0.610% | 0.27% |
| 22 | BALYASNY ASSET MANAGEMENT LLC | 237K | $5.7M | +6527.8% | 0.525% | 0.02% |
| 23 | Universal- Beteiligungs- und Servicegesellschaft mbH | 224K | $5.4M | +0.6% | 0.497% | 0.01% |
| 24 | VANGUARD PORTFOLIO MANAGEMENT LLC | 195K | $4.7M | β | 0.433% | 0.00% |
| 25 | Kalehua Capital Management LLC | 195K | $4.7M | 0.0% | 0.432% | 3.94% |
denotes a marquee investor (Buffett, Burry, ARK, Tiger Global, Pershing Square, Baupost and other widely-followed managers). β% of Fundβ shows how much of that investorβs total 13F portfolio is invested in SEPN β a direct measure of their conviction.
Filings activity in SEPN during Q1 2026, grouped by how each filer changed its position.
Institutions that opened a new SEPN position in Q1 2026
Institutions that fully closed their SEPN position in Q1 2026
6 quarters of 13F filings Β· Ξ columns show change vs prior quarter
| Quarter | Inst. Holders | Ξ Holders | Ownership % | Ξ Ownership | Total 13F Value | Ξ Value |
|---|---|---|---|---|---|---|
| Q1 2026 | 123 | +0.0% | 67.56% | 10.86 pp | $1.09B | 14% |
| Q4 2025 | 123 | +50% | 78.42% | +26.75 pp | $1.27B | +52% |
| Q3 2025 | 82 | 8.9% | 51.67% | +22.33 pp | $837M | +76% |
| Q2 2025 | 90 | +25% | 29.34% | +13.17 pp | $475M | +81% |
| Q1 2025 | 72 | +1.4% | 16.17% | 45.40 pp | $262M | 74% |
| Q4 2024 | 71 | β | 61.57% | β | $998M | β |
Source: SEC 13F institutional filings. Ownership % requires market cap data and will show once linked. Ξ columns compare to the immediately prior filed quarter.
Quick answers to the most common questions about buying SEPN stock.
Based on Q1 2026 13F filings, institutional ownership of Septerna, Inc. stands at 67.6%, held across 123 reporting institutions.
RA CAPITAL MANAGEMENT, L.P. is the largest reported institutional holder of SEPN, with approximately 6,995,858 shares worth $0.17B as of Q1 2026.
No marquee "smart money" managers (Berkshire, Burry, ARK, Tiger Global, Pershing Square, Baupost, etc.) currently appear among the top 25 institutional holders of SEPN.
Our composite Smart Money Score for SEPN is 27 out of 100 (Bearish). It combines net institutional buying activity, ownership shift, marquee investor presence, and holder-count growth.
28 institutions opened new positions in SEPN during Q1 2026, while 28 fully exited. 21 added to existing positions and 72 trimmed.
SEPN institutional ownership fell by 10.86 percentage points quarter-over-quarter, with a net change of +0 holders.
The top 10 institutions account for 75.5% of all reported 13F value in SEPN, and the top 25 account for 94.6%.
All data is sourced from SEC Form 13F filings, which institutional investment managers with at least $100M in assets are required to file each quarter. We process every 13F filing from EDGAR and recompute the aggregates after each cycle. Insider transactions are sourced from Form 4 filings.
Septerna, Inc. (SEPN) Institutional Ownership