Septerna, Inc. (SEPN) Revenue History
Annual and quarterly revenue from 2022 to 2025
Compound Annual Growth Rate (CAGR)
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SEPN Revenue Growth
SEPN Revenue Analysis (2022–2025)
As of May 8, 2026, Septerna, Inc. (SEPN) generated trailing twelve-month (TTM) revenue of $46.0 million, reflecting explosive growth of +11276.4% year-over-year. The most recent quarter (Q4 2025) recorded $24.1 million in revenue, up 12.2% sequentially.
Looking at the longer-term picture, SEPN's historical revenue data shows various trends over time. The company achieved its highest annual revenue of $46.0 million in 2025, representing a new all-time high.
When compared to Healthcare sector peers including KYMR (-12.6% YoY), RXRX (+11.0% YoY), and ACLX (-79.4% YoY), SEPN has outperformed the peer group in terms of revenue growth. Compare SEPN vs KYMR →
SEPN Revenue vs Peers
Revenue metrics vs comparable public companies
| Company | TTM Revenue | YoY Growth | 5Y CAGR | Op. Margin | Compare |
|---|---|---|---|---|---|
| SEPNCurrent | $46M | +11276.4% | - | -148.6% | |
 KYMR | $39M | -12.6% | +2.9% | -891.3% | |
 RXRX | $75M | +11.0% | +85.4% | -867.9% | |
 ACLX | $22M | -79.4% | - | -1135.6% |
SEPN Historical Revenue Data (2022–2025)
| Year | Revenue | YoY % | Gross Profit | Gross Margin | Op. Income | Op. Margin |
|---|---|---|---|---|---|---|
| 2025 | $46.0M | +4174.5% | $0 | - | $-68,297,000 | -148.6% |
| 2024 | $1.1M | +611.9% | $1.1M | 100.0% | $-80,823,000 | -7518.4% |
| 2023 | $151K | - | $151K | 100.0% | $2.1M | 1374.2% |
| 2022 | $0 | - | $0 | - | $-27,967,000 | - |
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Start ComparisonSEPN — Frequently Asked Questions
Quick answers to the most common questions about buying SEPN stock.
Is SEPN's revenue growth accelerating or slowing?
SEPN revenue is accelerating at +11276.4% year-over-year, exceeding the 5-year CAGR of N/A. TTM revenue reached $46M. Growth momentum has increased versus prior periods.
What is SEPN's long-term revenue growth rate?
Septerna, Inc.'s 5-year revenue CAGR of N/A reflects the sustained expansion pattern. Current YoY growth of +11276.4% is above this long-term average.
How is SEPN's revenue distributed by segment?
SEPN reports revenue by product line and geographic region. Annual and quarterly breakdowns from 2022-2025 are available for download. Segment mix reveals concentration and diversification trends.