Septerna, Inc. (SEPN) delivered a return of 236.60% over the past year. Since SEPN does not currently pay dividends, the total return equals the price-only return.

A $10,000 investment in Septerna, Inc. one year ago would be worth $33,660 today, representing a gain of $23,660.

Septerna, Inc. (SEPN) does not currently pay dividends. Many growth-focused companies reinvest profits back into the business rather than distributing them as dividends. For SEPN, the total return equals the price-only return.

Yes, Septerna, Inc. (SEPN) outperformed the S&P 500 by 215.76 percentage points over the past year. SEPN delivered a total return of 236.60%, compared to the S&P 500's 20.84%. This 215.76pp alpha means investors in SEPN earned more than a passive S&P 500 index fund.

Septerna, Inc. (SEPN) experienced a maximum drawdown of -25.18% over the past year, declining from its peak on 2026-02-24 to its trough on 2026-04-10. The stock recovered to its prior peak by 2026-05-28. Maximum drawdown measures the worst peak-to-trough decline and is an important risk metric for investors.

Here are Septerna, Inc. (SEPN)'s long-term returns with dividends reinvested. Over 10 years, the total return is 68.5% (5.4% CAGR) — $10,000 would have grown to $16,846. Over 20 years: 68.5% total return (2.6% CAGR) — $10,000 → $16,846. Over 30 years: 68.5% total return (1.8% CAGR) — $10,000 → $16,846. Long-term investors benefit from compounding: dividends buy additional shares, which generate their own dividends, creating an exponential growth effect.

Septerna, Inc.'s best calendar year was 2025 with a total return of 30.6%. Its worst year was 2024 with a total return of 7.0%. This range shows the volatility investors should expect — the difference between the best and worst year is 23.6 percentage points.