Septerna, Inc. (SEPN) Stock Price History
Historical prices from 2024 to 2026
- 1M
- +21.8%
- 3M
- +50.9%
- YTD
- +33.5%
- 1Y
- +243.5%
- 3Y
- +20.4%
- 5Y
- +11.8%
Loading 10-year price history...
SEPN Historical Performance
SEPN Annual Returns
Year-by-year price performance · 2024–2026
- 2024 annual price return
- +7.0%
- 2025 annual price return
- +30.6%
- 2026 annual price return
- +3.7%
SEPN Stock Price Trajectory (2024–2026)
As of June 29, 2026, Septerna, Inc. (SEPN) trades at $37.34, representing a +243.5% return over the past year. The stock has delivered a +68.5% total return over five years (+11.8% CAGR), reflecting significant long-term value creation.
The stock reached its all-time high of $37.99 on June 24, 2026. From this peak, SEPN has corrected -1.7%, currently trading 48% above its 200-day moving average, indicating continued institutional support.
When compared to Healthcare sector peers KYMR (+136.5% 1Y), RXRX (-34.8% 1Y), and VKTX (+35.0% 1Y), SEPN has outperformed the peer group average. Compare SEPN vs KYMR →
SEPN Historical Price Data · from 2024
Rows 1–50 of 418| Date | Open | High | Low | Close | Volume | Change % |
|---|---|---|---|---|---|---|
| 2026-06-26 | 34.44 | 37.48 | 34.43 | 37.34 | 0 | +8.11% |
| 2026-06-25 | 36.36 | 36.40 | 34.37 | 34.54 | 318K | -4.19% |
| 2026-06-24 | 36.90 | 37.99 | 35.61 | 36.05 | 347K | -1.42% |
| 2026-06-23 | 34.84 | 37.46 | 34.28 | 36.57 | 290K | +5.09% |
| 2026-06-22 | 36.46 | 37.38 | 34.68 | 34.80 | 466K | -3.79% |
| 2026-06-18 | 36.24 | 37.32 | 34.51 | 36.17 | 269K | +1.03% |
| 2026-06-17 | 35.17 | 36.12 | 33.88 | 35.80 | 315K | +1.79% |
| 2026-06-16 | 35.93 | 36.62 | 35.06 | 35.17 | 282K | -2.39% |
| 2026-06-15 | 36.27 | 37.00 | 35.37 | 36.03 | 89K | +0.22% |
| 2026-06-12 | 34.03 | 36.26 | 33.85 | 35.95 | 476K | +5.64% |
| 2026-06-11 | 30.86 | 34.18 | 30.74 | 34.03 | 508K | +11.68% |
| 2026-06-10 | 31.00 | 31.85 | 30.41 | 30.47 | 167K | -1.74% |
| 2026-06-09 | 30.69 | 31.90 | 30.23 | 31.01 | 268K | +1.97% |
| 2026-06-08 | 31.97 | 32.38 | 30.21 | 30.41 | 326K | -2.38% |
| 2026-06-05 | 30.90 | 31.41 | 30.39 | 31.15 | 197K | -0.70% |
| 2026-06-04 | 30.61 | 31.79 | 30.61 | 31.37 | 259K | +2.68% |
| 2026-06-03 | 29.89 | 30.84 | 29.57 | 30.55 | 282K | +2.04% |
| 2026-06-02 | 29.38 | 30.28 | 29.12 | 29.94 | 603K | -0.13% |
| 2026-06-01 | 29.59 | 30.36 | 27.07 | 29.98 | 359K | -0.73% |
| 2026-05-29 | 31.00 | 31.41 | 29.77 | 30.20 | 243K | -2.74% |
| 2026-05-28 | 29.97 | 31.40 | 29.22 | 31.05 | 216K | +4.23% |
| 2026-05-27 | 30.61 | 30.95 | 29.51 | 29.79 | 179K | -2.79% |
| 2026-05-26 | 28.49 | 30.76 | 27.66 | 30.64 | 347K | +8.06% |
| 2026-05-22 | 27.93 | 28.41 | 27.93 | 28.36 | 339K | +1.58% |
| 2026-05-21 | 27.62 | 28.59 | 27.49 | 27.92 | 232K | -0.32% |
| 2026-05-20 | 26.77 | 28.05 | 26.71 | 28.01 | 218K | +5.66% |
| 2026-05-19 | 25.95 | 27.16 | 25.79 | 26.51 | 363K | +0.80% |
| 2026-05-18 | 27.08 | 27.98 | 26.01 | 26.30 | 314K | -2.41% |
| 2026-05-15 | 27.62 | 28.80 | 26.28 | 26.95 | 559K | -4.84% |
| 2026-05-14 | 24.83 | 28.37 | 24.08 | 28.32 | 553K | +14.42% |
| 2026-05-13 | 24.50 | 25.48 | 24.24 | 24.75 | 309K | -0.36% |
| 2026-05-12 | 24.46 | 25.99 | 23.57 | 24.84 | 400K | +5.39% |
| 2026-05-11 | 24.08 | 24.65 | 23.50 | 23.57 | 128K | -1.26% |
| 2026-05-08 | 23.98 | 24.81 | 23.82 | 23.87 | 200K | -0.46% |
| 2026-05-07 | 24.77 | 25.05 | 23.44 | 23.98 | 216K | -3.26% |
| 2026-05-06 | 24.22 | 24.90 | 23.90 | 24.79 | 306K | +2.73% |
| 2026-05-05 | 25.00 | 25.25 | 23.29 | 24.13 | 88K | -2.78% |
| 2026-05-04 | 23.52 | 25.20 | 23.52 | 24.82 | 355K | +5.12% |
| 2026-05-01 | 23.84 | 24.59 | 23.15 | 23.61 | 190K | -0.63% |
| 2026-04-30 | 23.45 | 24.24 | 23.11 | 23.76 | 264K | +1.32% |
| 2026-04-29 | 24.00 | 24.57 | 22.78 | 23.45 | 338K | -3.46% |
| 2026-04-28 | 25.09 | 25.50 | 23.95 | 24.29 | 268K | -3.19% |
| 2026-04-27 | 24.60 | 25.86 | 24.60 | 25.09 | 364K | +1.70% |
| 2026-04-24 | 24.86 | 25.14 | 24.49 | 24.67 | 588K | -1.20% |
| 2026-04-23 | 25.82 | 26.49 | 24.94 | 24.97 | 333K | -3.44% |
| 2026-04-22 | 25.95 | 26.20 | 25.34 | 25.86 | 250K | +0.23% |
| 2026-04-21 | 26.37 | 27.30 | 25.52 | 25.80 | 347K | -3.95% |
| 2026-04-20 | 25.95 | 27.07 | 25.59 | 26.86 | 653K | +2.79% |
| 2026-04-17 | 25.50 | 26.57 | 24.84 | 26.13 | 379K | +4.56% |
| 2026-04-16 | 25.92 | 26.85 | 24.98 | 24.99 | 345K | -3.63% |
Intrinsic Valuation
DCF models, multiple analysis, and analyst estimates.
Historical Returns
10-year return with dividends reinvested.
DCA Calculator
See how regular investing compounds over time.
Peer Comparison
Compare growth, multiples, and margins vs sector.
SEPN — Frequently Asked Questions
Quick answers to the most common questions about buying SEPN stock.
How has SEPN stock performed recently?
SEPN returned +243.5% over the past year, beating its 5-year annualized CAGR of +11.8%. The stock trades above its 200-day moving average, confirming the uptrend.
What is SEPN's all-time high price?
Septerna, Inc. reached $37.99 on 2026-06-24. The 52-week high is $37.99. Current 1-year return of +243.5% places the stock closer to historical peaks.
Where can I download SEPN historical price data?
This page provides SEPN daily OHLCV data with 50-day MA, 200-day MA, and RSI indicators. Data spans 2024-2026, downloadable in CSV format.