Septerna, Inc. (SEPN) Stock Price History
Historical prices from 2024 to 2026
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SEPN Historical Performance
Short-Term Returns
SEPN Stock Price Trajectory (2024–2026)
As of May 8, 2026, Septerna, Inc. (SEPN) trades at $23.98, representing a +240.1% return over the past year. The stock has delivered a +12.1% total return over five years (+2.3% CAGR), reflecting significant long-term value creation.
The stock reached its all-time high of $32.63 on February 25, 2026. From this peak, SEPN has corrected -26.5%, currently trading 8% above its 200-day moving average, indicating continued institutional support.
When compared to Healthcare sector peers KYMR (+190.7% 1Y), RXRX (-22.0% 1Y), and VKTX (+14.6% 1Y), SEPN has outperformed the peer group average. Compare SEPN vs KYMR →
SEPN Historical Price Data (2025–2026)
Showing 30 of 384 recordsLoading full history…
| Date | Open | High | Low | Close | Volume | Change % |
|---|---|---|---|---|---|---|
| 2026-05-07 | 24.77 | 25.05 | 23.44 | 23.98 | 216K | -3.26% |
| 2026-05-06 | 24.22 | 24.90 | 23.90 | 24.79 | 306K | +2.73% |
| 2026-05-05 | 25.00 | 25.25 | 23.29 | 24.13 | 88K | -2.78% |
| 2026-05-04 | 23.52 | 25.20 | 23.52 | 24.82 | 355K | +5.12% |
| 2026-05-01 | 23.84 | 24.59 | 23.15 | 23.61 | 190K | -0.63% |
| 2026-04-30 | 23.45 | 24.24 | 23.11 | 23.76 | 264K | +1.32% |
| 2026-04-29 | 24.00 | 24.57 | 22.78 | 23.45 | 338K | -3.46% |
| 2026-04-28 | 25.09 | 25.50 | 23.95 | 24.29 | 268K | -3.19% |
| 2026-04-27 | 24.60 | 25.86 | 24.60 | 25.09 | 364K | +1.70% |
| 2026-04-24 | 24.86 | 25.14 | 24.49 | 24.67 | 588K | -1.20% |
| 2026-04-23 | 25.82 | 26.49 | 24.94 | 24.97 | 333K | -3.44% |
| 2026-04-22 | 25.95 | 26.20 | 25.34 | 25.86 | 250K | +0.23% |
| 2026-04-21 | 26.37 | 27.30 | 25.52 | 25.80 | 347K | -3.95% |
| 2026-04-20 | 25.95 | 27.07 | 25.59 | 26.86 | 653K | +2.79% |
| 2026-04-17 | 25.50 | 26.57 | 24.84 | 26.13 | 379K | +4.56% |
| 2026-04-16 | 25.92 | 26.85 | 24.98 | 24.99 | 345K | -3.63% |
| 2026-04-15 | 24.13 | 25.98 | 23.31 | 25.93 | 807K | +7.46% |
| 2026-04-14 | 23.62 | 24.40 | 23.35 | 24.13 | 208K | +3.38% |
| 2026-04-13 | 23.00 | 24.33 | 22.90 | 23.34 | 212K | +1.08% |
| 2026-04-10 | 24.92 | 24.92 | 22.97 | 23.09 | 622K | -7.01% |
| 2026-04-09 | 24.40 | 25.21 | 24.18 | 24.83 | 208K | +1.39% |
| 2026-04-08 | 25.71 | 25.83 | 24.22 | 24.49 | 157K | -1.41% |
| 2026-04-07 | 24.67 | 24.86 | 24.05 | 24.84 | 185K | +0.24% |
| 2026-04-06 | 25.20 | 25.27 | 24.38 | 24.78 | 138K | -1.59% |
| 2026-04-02 | 24.14 | 25.29 | 23.90 | 25.18 | 280K | +3.32% |
| 2026-04-01 | 24.33 | 24.94 | 24.21 | 24.37 | 197K | +1.41% |
| 2026-03-31 | 23.74 | 24.30 | 23.50 | 24.03 | 252K | +3.13% |
| 2026-03-30 | 23.95 | 24.17 | 22.89 | 23.30 | 223K | -2.39% |
| 2026-03-27 | 25.00 | 25.16 | 23.75 | 23.87 | 140K | -3.52% |
| 2026-03-26 | 23.98 | 25.00 | 23.40 | 24.74 | 232K | +2.19% |
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Start ComparisonSEPN — Frequently Asked Questions
Quick answers to the most common questions about buying SEPN stock.
How has SEPN stock performed recently?
SEPN returned +240.1% over the past year, beating its 5-year annualized CAGR of +2.3%. The stock trades above its 200-day moving average, confirming the uptrend.
What is SEPN's all-time high price?
Septerna, Inc. reached $32.63 on 2026-02-25. The 52-week high is $32.63. Current 1-year return of +240.1% places the stock closer to historical peaks.
Where can I download SEPN historical price data?
This page provides SEPN daily OHLCV data with 50-day MA, 200-day MA, and RSI indicators. Data spans 2024-2026, downloadable in CSV format.