Ranked by reported Q2 2026 13F market value
Share of total reported institutional value in XENE held by the largest 10 / 25 filers.
| # | Institution | Shares Held | Market Value | QoQ Change | Ownership % | % of Fund |
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 9.6M | $582.4M | -10.8% | 9.981% | 0.03% |
| 2 | BlackRock, Inc. | 7.5M | $454.1M | +33.4% | 7.782% | 0.01% |
| 3 | Avoro Capital Advisors LLC | 5.8M | $348.7M | 0.0% | 5.977% | 3.13% |
| 4 | Polar Capital Holdings Plc | 4.6M | $275.9M | +3.8% | 4.728% | 0.65% |
| 5 | DRIEHAUS CAPITAL MANAGEMENT LLC | 4.4M | $266.7M | -1.6% | 4.571% | 1.55% |
| 6 | Jupiter Topco LLC | 4.2M | $252.7M | — | 4.331% | 0.10% |
| 7 | JPMORGAN CHASE & CO | 2.6M | $157.4M | +36.1% | 2.708% | 0.01% |
| 8 | Capital International Investors | 2.4M | $142.5M | -11.7% | 2.443% | 0.03% |
| 9 | STATE STREET CORP | 2.0M | $118.9M | +14.5% | 2.038% | 0.00% |
| 10 | TWO SIGMA INVESTMENTS, LP | 1.6M | $99.2M | +171.1% | 1.700% | 0.07% |
| 11 | DEERFIELD MANAGEMENT COMPANY, L.P. | 1.6M | $97.5M | 0.0% | 1.671% | 1.02% |
| 12 | Affinity Asset Advisors, LLC | 1.6M | $96.3M | -4.8% | 1.650% | 4.35% |
| 13 | WESTFIELD CAPITAL MANAGEMENT CO LP | 1.5M | $91.0M | +7.5% | 1.559% | 0.30% |
| 14 | ALLIANCEBERNSTEIN L.P. | 1.6M | $90.8M | +11.3% | 1.616% | 0.03% |
| 15 | CITADEL ADVISORS LLC | 1.4M | $87.4M | -49.8% | 1.498% | 0.00% |
| 16 | FRANKLIN TEMPLETON INC | 1.4M | $86.8M | +12.3% | 1.487% | 0.02% |
| 17 | WELLINGTON MANAGEMENT GROUP LLP | 1.4M | $86.0M | -70.5% | 1.475% | 0.01% |
| 18 | GEODE CAPITAL MANAGEMENT, LLC | 1.4M | $82.7M | +25.4% | 1.417% | 0.00% |
| 19 | Siren, L.L.C. | 1.3M | $79.6M | 0.0% | 1.364% | 1.61% |
| 20 | BNP Paribas Asset Management Holding S.A. | 1.3M | $77.9M | -3.8% | 1.335% | 0.08% |
| 21 | Pictet Asset Management Holding SA | 1.2M | $71.6M | +74.7% | 1.229% | 0.07% |
| 22 | BRAIDWELL LP | 1.1M | $68.3M | -15.5% | 1.171% | 2.53% |
| 23 | Nuveen, LLC | 993K | $59.9M | +297.2% | 1.027% | 0.01% |
| 24 | Invesco Ltd. | 903K | $54.5M | +1428.6% | 0.935% | 0.00% |
| 25 | ORBIMED ADVISORS LLC | 892K | $53.9M | -15.8% | 0.923% | 1.00% |
denotes a marquee investor (Buffett, Burry, ARK, Tiger Global, Pershing Square, Baupost and other widely-followed managers). “% of Fund” shows how much of that investor’s total 13F portfolio is invested in XENE — a direct measure of their conviction.
Filings activity in XENE during Q2 2026, grouped by how each filer changed its position.
8 quarters of 13F filings · Δ columns show change vs prior quarter
| Quarter | Inst. Holders | Δ Holders | Ownership % | Δ Ownership | Total 13F Value | Δ Value |
|---|---|---|---|---|---|---|
| Q2 2026 | 315 | +7.9% | 105.65% | 2.23 pp | $5.80B | 1.1% |
| Q1 2026 | 292 | +17% | 107.88% | +0.66 pp | $5.87B | +57% |
| Q4 2025 | 250 | +16% | 107.22% | 2.86 pp | $3.74B | +12% |
| Q3 2025 | 215 | +5.9% | 110.08% | +1.78 pp | $3.34B | +30% |
| Q2 2025 | 203 | 0.5% | 108.30% | +9.05 pp | $2.56B | +4.3% |
| Q1 2025 | 204 | 1.9% | 99.25% | 0.27 pp | $2.46B | 13% |
| Q4 2024 | 208 | +5.1% | 99.52% | +1.60 pp | $2.83B | +2.3% |
| Q3 2024 | 198 | — | 97.92% | — | $2.77B | — |
Source: SEC 13F institutional filings. Ownership % requires market cap data and will show once linked. Δ columns compare to the immediately prior filed quarter.
Quick answers to the most common questions about buying XENE stock.
Based on Q2 2026 13F filings, institutional ownership of Xenon Pharmaceuticals Inc. stands at 105.7%, held across 315 reporting institutions.
FMR LLC is the largest reported institutional holder of XENE, with approximately 9,647,998 shares worth $0.58B as of Q2 2026.
Yes — 2 widely-followed marquee investors appear among the top 25 institutional holders of XENE, including TWO SIGMA INVESTMENTS, LP, CITADEL ADVISORS LLC.
Our composite Smart Money Score for XENE is 50 out of 100 (Neutral). It combines net institutional buying activity, ownership shift, marquee investor presence, and holder-count growth.
44 institutions opened new positions in XENE during Q2 2026, while 22 fully exited. 196 added to existing positions and 69 trimmed.
XENE institutional ownership fell by 2.23 percentage points quarter-over-quarter, with a net change of +23 holders.
The top 10 institutions account for 46.5% of all reported 13F value in XENE, and the top 25 account for 66.9%.
All data is sourced from SEC Form 13F filings, which institutional investment managers with at least $100M in assets are required to file each quarter. We process every 13F filing from EDGAR and recompute the aggregates after each cycle. Insider transactions are sourced from Form 4 filings.
Xenon Pharmaceuticals Inc. (XENE) Institutional Ownership