Ranked by reported Q1 2026 13F market value
Share of total reported institutional value in XENE held by the largest 10 / 25 filers.
| # | Institution | Shares Held | Market Value | QoQ Change | Ownership % | % of Fund |
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 10.8M | $629.1M | +21.3% | 13.703% | 0.03% |
| 2 | Avoro Capital Advisors LLC | 5.8M | $336.0M | +6.5% | 7.319% | 3.44% |
| 3 | BlackRock, Inc. | 5.6M | $328.0M | +10.6% | 7.144% | 0.01% |
| 4 | WELLINGTON MANAGEMENT GROUP LLP | 4.8M | $280.8M | +1.4% | 6.117% | 0.05% |
| 5 | DRIEHAUS CAPITAL MANAGEMENT LLC | 4.5M | $261.2M | -1.0% | 5.689% | 1.92% |
| 6 | Polar Capital Holdings Plc | 4.4M | $256.2M | +78.7% | 5.580% | 0.91% |
| 7 | JANUS HENDERSON GROUP PLC | 4.2M | $242.9M | +2.3% | 5.290% | 0.12% |
| 8 | CITADEL ADVISORS LLC | 2.9M | $167.8M | +101.9% | 3.656% | 0.08% |
| 9 | Capital International Investors | 2.7M | $155.5M | -21.7% | 3.388% | 0.04% |
| 10 | STATE STREET CORP | 1.7M | $100.0M | +15.3% | 2.179% | 0.00% |
| 11 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 1.7M | $98.6M | +1136.2% | 2.147% | 0.01% |
| 12 | Affinity Asset Advisors, LLC | 1.7M | $97.4M | +34.0% | 2.122% | 5.67% |
| 13 | DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C) | 1.6M | $94.0M | +198.1% | 2.046% | 1.11% |
| 14 | Holocene Advisors, LP | 1.5M | $88.3M | +18.4% | 1.924% | 0.21% |
| 15 | WESTFIELD CAPITAL MANAGEMENT CO LP | 1.4M | $81.5M | +14.2% | 1.775% | 0.34% |
| 16 | Caligan Partners LP | 1.4M | $81.0M | +26.7% | 1.765% | 5.63% |
| 17 | BNP Paribas Asset Management Holding S.A. | 1.3M | $78.0M | +26.6% | 1.700% | 0.09% |
| 18 | BRAIDWELL LP | 1.3M | $77.8M | -26.7% | 1.695% | 2.60% |
| 19 | JENNISON ASSOCIATES LLC | 1.3M | $76.7M | +2.1% | 1.671% | 0.05% |
| 20 | Siren, L.L.C. | 1.3M | $76.7M | +62.2% | 1.670% | 2.13% |
| 21 | Alyeska Investment Group, L.P. | 1.3M | $75.6M | — | 1.646% | 0.21% |
| 22 | FRANKLIN RESOURCES INC | 1.3M | $74.5M | +68.9% | 1.622% | 0.02% |
| 23 | GEODE CAPITAL MANAGEMENT, LLC | 1.1M | $63.5M | +14.7% | 1.384% | 0.00% |
| 24 | ALLIANCEBERNSTEIN L.P. | 1.4M | $62.9M | -11.9% | 1.777% | 0.02% |
| 25 | ORBIMED ADVISORS LLC | 1.1M | $61.6M | +137.0% | 1.343% | 1.30% |
denotes a marquee investor (Buffett, Burry, ARK, Tiger Global, Pershing Square, Baupost and other widely-followed managers). “% of Fund” shows how much of that investor’s total 13F portfolio is invested in XENE — a direct measure of their conviction.
Filings activity in XENE during Q1 2026, grouped by how each filer changed its position.
8 quarters of 13F filings · Δ columns show change vs prior quarter
| Quarter | Inst. Holders | Δ Holders | Ownership % | Δ Ownership | Total 13F Value | Δ Value |
|---|---|---|---|---|---|---|
| Q1 2026 | 281 | +15% | 136.79% | +46.91 pp | $5.63B | +52% |
| Q4 2025 | 245 | +16% | 89.88% | +10.20 pp | $3.70B | +13% |
| Q3 2025 | 211 | +3.9% | 79.68% | +17.38 pp | $3.28B | +28% |
| Q2 2025 | 203 | 0.5% | 62.30% | +2.59 pp | $2.56B | +4.3% |
| Q1 2025 | 204 | 1.9% | 59.71% | 9.15 pp | $2.46B | 13% |
| Q4 2024 | 208 | +5.1% | 68.86% | +1.54 pp | $2.83B | +2.3% |
| Q3 2024 | 198 | 4.8% | 67.32% | +1.33 pp | $2.77B | +2.0% |
| Q2 2024 | 208 | — | 65.99% | — | $2.71B | — |
Source: SEC 13F institutional filings. Ownership % requires market cap data and will show once linked. Δ columns compare to the immediately prior filed quarter.
Quick answers to the most common questions about buying XENE stock.
Based on Q1 2026 13F filings, institutional ownership of Xenon Pharmaceuticals Inc. stands at 136.8%, held across 281 reporting institutions.
FMR LLC is the largest reported institutional holder of XENE, with approximately 10,818,491 shares worth $0.63B as of Q1 2026.
Yes — 2 widely-followed marquee investors appear among the top 25 institutional holders of XENE, including CITADEL ADVISORS LLC, SUSQUEHANNA INTERNATIONAL GROUP, LLP.
Our composite Smart Money Score for XENE is 74 out of 100 (Bullish). It combines net institutional buying activity, ownership shift, marquee investor presence, and holder-count growth.
75 institutions opened new positions in XENE during Q1 2026, while 39 fully exited. 175 added to existing positions and 29 trimmed.
XENE institutional ownership rose by 46.91 percentage points quarter-over-quarter, with a net change of +36 holders.
The top 10 institutions account for 49.0% of all reported 13F value in XENE, and the top 25 account for 70.1%.
All data is sourced from SEC Form 13F filings, which institutional investment managers with at least $100M in assets are required to file each quarter. We process every 13F filing from EDGAR and recompute the aggregates after each cycle. Insider transactions are sourced from Form 4 filings.
Xenon Pharmaceuticals Inc. (XENE) Institutional Ownership