Biotechnology
Compare Stocks
4 / 10Stock Comparison
NBY vs PCYO vs MSEX vs AYTU
Revenue, margins, valuation, and 5-year total return — side by side.
Regulated Water
Regulated Water
Drug Manufacturers - Specialty & Generic
NBY vs PCYO vs MSEX vs AYTU — Key Financials
Market cap, revenue, margins, and valuation side-by-side.
| Company Snapshot | ||||
|---|---|---|---|---|
| Industry | Biotechnology | Regulated Water | Regulated Water | Drug Manufacturers - Specialty & Generic |
| Market Cap | $11M | $281M | $955M | $16M |
| Revenue (TTM) | $3M | $29M | $199M | $63M |
| Net Income (TTM) | $3M | $14M | $44M | $-24M |
| Gross Margin | 54.6% | 58.9% | 33.3% | 66.0% |
| Operating Margin | -273.0% | 35.1% | 28.1% | -13.9% |
| Forward P/E | — | 21.6x | 20.1x | — |
| Total Debt | $2M | $7M | $419M | $23M |
| Cash & Equiv. | $430K | $22M | $3M | $31M |
NBY vs PCYO vs MSEX vs AYTU — Long-Term Stock Performance
Price return indexed to 100 at period start. Dividends excluded.
| Stock | May 20 | Apr 26 | Return |
|---|---|---|---|
| NovaBay Pharmaceuti… (NBY) | 100 | 0.0 | -100.0% |
| Pure Cycle Corporat… (PCYO) | 100 | 99.0 | -1.0% |
| Middlesex Water Com… (MSEX) | 100 | 76.7 | -23.3% |
| Aytu BioPharma, Inc. (AYTU) | 100 | 0.9 | -99.1% |
Price return only. Dividends and distributions are not included.
Quick Verdict: NBY vs PCYO vs MSEX vs AYTU
Each card shows where this stock fits in a portfolio — not just who wins on paper.
NBY has the current edge in this matchup, primarily because of its strength in quality and efficiency.
- 114.6% margin vs AYTU's -39.0%
- 93.0% ROA vs AYTU's -20.0%, ROIC -217.0% vs -33.5%
PCYO is the #2 pick in this set and the best alternative if income & stability and long-term compounding is your priority.
- beta 0.79
- 159.6% 10Y total return vs MSEX's 62.9%
- Lower volatility, beta 0.79, Low D/E 4.8%, current ratio 2.72x
- PEG 1.54 vs MSEX's 12.58
MSEX is the clearest fit if your priority is dividends.
- 2.7% yield; 21-year raise streak; the other 3 pay no meaningful dividend
AYTU is the clearest fit if your priority is growth exposure.
- Rev growth 1.8%, EPS growth 24.5%, 3Y rev CAGR -11.8%
- 1.8% revenue growth vs PCYO's -9.3%
- +104.1% vs MSEX's -12.8%
See the full category breakdown
| Category | Winner | Why |
|---|---|---|
| Growth | 1.8% revenue growth vs PCYO's -9.3% | |
| Value | Better valuation composite | |
| Quality / Margins | 114.6% margin vs AYTU's -39.0% | |
| Stability / Safety | Beta 0.79 vs NBY's 2.43 | |
| Dividends | 2.7% yield; 21-year raise streak; the other 3 pay no meaningful dividend | |
| Momentum (1Y) | +104.1% vs MSEX's -12.8% | |
| Efficiency (ROA) | 93.0% ROA vs AYTU's -20.0%, ROIC -217.0% vs -33.5% |
NBY vs PCYO vs MSEX vs AYTU — Revenue Breakdown by Segment
How each company's revenue is distributed across its business units
NBY vs PCYO vs MSEX vs AYTU — Financial Metrics
Side-by-side numbers across 4 stocks — who leads on profitability, valuation, growth, and risk.
Who Leads Where
AYTU leads in 1 of 6 categories
PCYO leads 1 • NBY leads 0 • MSEX leads 0 • 3 tied
Explore the data ↓Income & Cash Flow (Last 12 Months)
Evenly matched — NBY and PCYO and AYTU each lead in 2 of 6 comparable metrics.
Income & Cash Flow (Last 12 Months)
MSEX is the larger business by revenue, generating $199M annually — 70.4x NBY's $3M. NBY is the more profitable business, keeping 114.6% of every revenue dollar as net income compared to AYTU's -39.0%. On growth, PCYO holds the edge at +58.8% YoY revenue growth, suggesting stronger near-term business momentum.
| Metric | ||||
|---|---|---|---|---|
| RevenueTrailing 12 months | $3M | $29M | $199M | $63M |
| EBITDAEarnings before interest/tax | -$8M | $13M | $81M | -$4M |
| Net IncomeAfter-tax profit | $3M | $14M | $44M | -$24M |
| Free Cash FlowCash after capex | -$7M | -$2M | -$19M | -$698,000 |
| Gross MarginGross profit ÷ Revenue | +54.6% | +58.9% | +33.3% | +66.0% |
| Operating MarginEBIT ÷ Revenue | -2.7% | +35.1% | +28.1% | -13.9% |
| Net MarginNet income ÷ Revenue | +114.6% | +46.6% | +22.1% | -39.0% |
| FCF MarginFCF ÷ Revenue | -2.5% | -7.5% | -9.7% | -1.1% |
| Rev. Growth (YoY)Latest quarter vs prior year | -78.7% | +58.8% | +10.0% | -6.5% |
| EPS Growth (YoY)Latest quarter vs prior year | +63.3% | +18.8% | -100.0% | -3.0% |
Valuation Metrics
AYTU leads this category, winning 3 of 5 comparable metrics.
Valuation Metrics
At 21.6x trailing earnings, PCYO trades at a 1% valuation discount to MSEX's 21.8x P/E. Adjusting for growth (PEG ratio), PCYO offers better value at 1.54x vs MSEX's 13.62x — a lower PEG means you pay less per unit of expected earnings growth.
| Metric | ||||
|---|---|---|---|---|
| Market CapShares × price | $11M | $281M | $955M | $16M |
| Enterprise ValueMkt cap + debt − cash | $13M | $266M | $1.4B | $7M |
| Trailing P/EPrice ÷ TTM EPS | -0.74x | 21.63x | 21.78x | -1.14x |
| Forward P/EPrice ÷ next-FY EPS est. | — | — | 20.12x | — |
| PEG RatioP/E ÷ EPS growth rate | — | 1.54x | 13.62x | — |
| EV / EBITDAEnterprise value multiple | — | 26.71x | 15.79x | — |
| Price / SalesMarket cap ÷ Revenue | 1.16x | 10.79x | 4.91x | 0.23x |
| Price / BookPrice ÷ Book value/share | — | 1.98x | 1.89x | 0.82x |
| Price / FCFMarket cap ÷ FCF | — | 76.23x | — | — |
Profitability & Efficiency
PCYO leads this category, winning 6 of 9 comparable metrics.
Profitability & Efficiency
NBY delivers a 198.5% return on equity — every $100 of shareholder capital generates $198 in annual profit, vs $-172 for AYTU. PCYO carries lower financial leverage with a 0.05x debt-to-equity ratio, signaling a more conservative balance sheet compared to AYTU's 1.21x. On the Piotroski fundamental quality scale (0–9), PCYO scores 5/9 vs AYTU's 3/9, reflecting solid financial health.
| Metric | ||||
|---|---|---|---|---|
| ROE (TTM)Return on equity | +198.5% | +9.3% | +9.1% | -172.1% |
| ROA (TTM)Return on assets | +93.0% | +8.2% | +3.2% | -20.0% |
| ROICReturn on invested capital | -2.2% | +4.7% | +4.7% | -33.5% |
| ROCEReturn on capital employed | -2.2% | +5.3% | +4.4% | -13.3% |
| Piotroski ScoreFundamental quality 0–9 | 3 | 5 | 4 | 3 |
| Debt / EquityFinancial leverage | — | 0.05x | 0.85x | 1.21x |
| Net DebtTotal debt minus cash | $1M | -$15M | $416M | -$8M |
| Cash & Equiv.Liquid assets | $430,000 | $22M | $3M | $31M |
| Total DebtShort + long-term debt | $2M | $7M | $419M | $23M |
| Interest CoverageEBIT ÷ Interest expense | -89.97x | 18.00x | 4.33x | -7.96x |
Total Returns (Dividends Reinvested)
Evenly matched — PCYO and AYTU each lead in 3 of 6 comparable metrics.
Total Returns (Dividends Reinvested)
A $10,000 investment in PCYO five years ago would be worth $8,016 today (with dividends reinvested), compared to $13 for NBY. Over the past 12 months, AYTU leads with a +104.1% total return vs MSEX's -12.8%. The 3-year compound annual growth rate (CAGR) favors AYTU at 12.0% vs NBY's -67.4% — a key indicator of consistent wealth creation.
| Metric | ||||
|---|---|---|---|---|
| YTD ReturnYear-to-date | -93.6% | +8.0% | +3.0% | -10.8% |
| 1-Year ReturnPast 12 months | +102.8% | +12.5% | -12.8% | +104.1% |
| 3-Year ReturnCumulative with dividends | -96.5% | +27.2% | -25.2% | +40.3% |
| 5-Year ReturnCumulative with dividends | -99.9% | -19.8% | -28.4% | -97.8% |
| 10-Year ReturnCumulative with dividends | -100.0% | +159.6% | +62.9% | -100.0% |
| CAGR (3Y)Annualised 3-year return | -67.4% | +8.4% | -9.2% | +12.0% |
Risk & Volatility
Evenly matched — PCYO and MSEX each lead in 1 of 2 comparable metrics.
Risk & Volatility
MSEX is the less volatile stock with a -0.12 beta — it tends to amplify market swings less than NBY's 2.43 beta. A beta below 1.0 means the stock typically moves less than the S&P 500. PCYO currently trades 96.1% from its 52-week high vs NBY's 1.9% drawdown — a narrower gap to the peak suggests stronger recent price momentum.
| Metric | ||||
|---|---|---|---|---|
| Beta (5Y)Sensitivity to S&P 500 | 2.43x | 0.79x | -0.12x | 1.27x |
| 52-Week HighHighest price in past year | $99.75 | $12.15 | $62.18 | $3.07 |
| 52-Week LowLowest price in past year | $1.11 | $9.65 | $44.17 | $1.20 |
| % of 52W HighCurrent price vs 52-week peak | +1.9% | +96.1% | +82.7% | +80.5% |
| RSI (14)Momentum oscillator 0–100 | 42.5 | 57.9 | 44.1 | 48.9 |
| Avg Volume (50D)Average daily shares traded | 595K | 54K | 160K | 42K |
Analyst Outlook
Insufficient data to determine a leader in this category.
Analyst Outlook
Analyst consensus: PCYO as "Buy", MSEX as "Buy". MSEX is the only dividend payer here at 2.67% yield — a key consideration for income-focused portfolios.
| Metric | ||||
|---|---|---|---|---|
| Analyst RatingConsensus buy/hold/sell | — | Buy | Buy | — |
| Price TargetConsensus 12-month target | — | — | $53.50 | — |
| # AnalystsCovering analysts | — | 1 | 4 | — |
| Dividend YieldAnnual dividend ÷ price | — | — | +2.7% | — |
| Dividend StreakConsecutive years of raises | — | — | 21 | — |
| Dividend / ShareAnnual DPS | — | — | $1.37 | — |
| Buyback YieldShare repurchases ÷ mkt cap | 0.0% | +0.1% | 0.0% | 0.0% |
AYTU leads in 1 of 6 categories (Valuation Metrics). PCYO leads in 1 (Profitability & Efficiency). 3 tied.
NBY vs PCYO vs MSEX vs AYTU: Key Questions Answered
9 questions · data-driven answers · updated daily
01Is NBY or PCYO or MSEX or AYTU a better buy right now?
For growth investors, Aytu BioPharma, Inc.
(AYTU) is the stronger pick with 1. 8% revenue growth year-over-year, versus -9. 3% for Pure Cycle Corporation (PCYO). Pure Cycle Corporation (PCYO) offers the better valuation at 21. 6x trailing P/E, making it the more compelling value choice. Analysts rate Pure Cycle Corporation (PCYO) a "Buy" — based on 1 analyst ratings — the highest consensus in this comparison. The "better buy" depends entirely on your goals: growth investors should weight revenue trajectory, value investors should weight P/E and PEG, and income investors should weight dividend yield and streak.
02Which has the better valuation — NBY or PCYO or MSEX or AYTU?
On trailing P/E, Pure Cycle Corporation (PCYO) is the cheapest at 21.
6x versus Middlesex Water Company at 21. 8x.
03Which is the better long-term investment — NBY or PCYO or MSEX or AYTU?
Over the past 5 years, Pure Cycle Corporation (PCYO) delivered a total return of -19.
8%, compared to -99. 9% for NovaBay Pharmaceuticals, Inc. (NBY). Over 10 years, the gap is even starker: PCYO returned +159. 6% versus AYTU's -100. 0%. Past returns do not guarantee future results, and the stock with the higher historical return may already have its best growth priced in.
04Which is safer — NBY or PCYO or MSEX or AYTU?
By beta (market sensitivity over 5 years), Middlesex Water Company (MSEX) is the lower-risk stock at -0.
12β versus NovaBay Pharmaceuticals, Inc. 's 2. 43β — meaning NBY is approximately -2056% more volatile than MSEX relative to the S&P 500. On balance sheet safety, Pure Cycle Corporation (PCYO) carries a lower debt/equity ratio of 5% versus 121% for Aytu BioPharma, Inc. — giving it more financial flexibility in a downturn.
05Which is growing faster — NBY or PCYO or MSEX or AYTU?
By revenue growth (latest reported year), Aytu BioPharma, Inc.
(AYTU) is pulling ahead at 1. 8% versus -9. 3% for Pure Cycle Corporation (PCYO). On earnings-per-share growth, the picture is similar: NovaBay Pharmaceuticals, Inc. grew EPS 98. 2% year-over-year, compared to -4. 5% for Middlesex Water Company. Over a 3-year CAGR, MSEX leads at 6. 2% annualised revenue growth. Higher growth typically commands a higher valuation multiple — check whether the premium P/E or P/S is justified by the growth rate using the PEG ratio.
06Which has better profit margins — NBY or PCYO or MSEX or AYTU?
Pure Cycle Corporation (PCYO) is the more profitable company, earning 50.
3% net margin versus -73. 8% for NovaBay Pharmaceuticals, Inc. — meaning it keeps 50. 3% of every revenue dollar as bottom-line profit. Operating margin tells a similar story: PCYO leads at 29. 4% versus -59. 7% for NBY. At the gross margin level — before operating expenses — AYTU leads at 69. 0%, reflecting greater pricing power or product mix advantage. Stronger margins indicate durable pricing power, lower cost of revenue, or higher mix of software/services. They are one of the clearest signs of business quality.
07Which pays a better dividend — NBY or PCYO or MSEX or AYTU?
In this comparison, MSEX (2.
7% yield) pays a dividend. NBY, PCYO, AYTU do not pay a meaningful dividend and should not be held primarily for income.
08Is NBY or PCYO or MSEX or AYTU better for a retirement portfolio?
For long-horizon retirement investors, Middlesex Water Company (MSEX) is the stronger choice — it scores higher on the combination of lower volatility, dividend reliability, and long-term compounding (low volatility (β -0.
12), 2. 7% yield). NovaBay Pharmaceuticals, Inc. (NBY) carries a higher beta of 2. 43 — meaning larger drawdowns in market downturns, which matters significantly when you cannot wait years for a recovery. Both have compounded well over 10 years (MSEX: +62. 9%, NBY: -100. 0%), confirming both are viable long-term holds — but the lower-volatility option typically results in less emotional selling during corrections. Retirement portfolios generally favour predictability over maximum returns. Consult a financial advisor before making allocation decisions.
09What are the main differences between NBY and PCYO and MSEX and AYTU?
These companies operate in different sectors (NBY (Healthcare) and PCYO (Utilities) and MSEX (Utilities) and AYTU (Healthcare)), which means they face different economic cycles, regulatory environments, and macro sensitivities — making direct comparison nuanced.
MSEX pays a dividend while NBY, PCYO, AYTU do not, making them suitable for different income and tax situations. These fundamental differences mean investors should not choose between them on a single metric — the "better stock" depends entirely on which of these characteristics aligns with your investment strategy.
Find Stocks Like These
Explore pre-built screens for each stock's profile, or build a custom screen to find stocks that outperform all of them.
You Might Also Compare
Based on how these companies actually compete and overlap — not just which sector they're filed under.