Ranked by reported Q1 2026 13F market value
Share of total reported institutional value in MDGL held by the largest 10 / 25 filers.
| # | Institution | Shares Held | Market Value | QoQ Change | Ownership % | % of Fund |
|---|---|---|---|---|---|---|
| 1 | BAKER BROS. ADVISORS LP | 2.1M | $1.12B | 0.0% | 9.289% | 6.44% |
| 2 | JANUS HENDERSON GROUP PLC | 2.0M | $1.05B | +27.4% | 8.755% | 0.52% |
| 3 | RTW INVESTMENTS, LP | 2.0M | $1.04B | 0.0% | 8.647% | 10.38% |
| 4 | Avoro Capital Advisors LLC | 1.8M | $951.8M | +0.6% | 7.886% | 9.74% |
| 5 | BlackRock, Inc. | 1.6M | $816.6M | -5.1% | 6.766% | 0.01% |
| 6 | PAULSON & CO. INC. | 1.4M | $728.8M | -18.5% | 6.038% | 23.42% |
| 7 | VANGUARD PORTFOLIO MANAGEMENT LLC | 841K | $440.3M | — | 3.648% | 0.02% |
| 8 | VANGUARD CAPITAL MANAGEMENT LLC | 827K | $433.0M | — | 3.588% | 0.01% |
| 9 | WELLINGTON MANAGEMENT GROUP LLP | 695K | $363.8M | +50.6% | 3.014% | 0.07% |
| 10 | STATE STREET CORP | 610K | $319.1M | +4.5% | 2.644% | 0.01% |
| 11 | CITADEL ADVISORS LLC | 603K | $315.4M | +227.2% | 2.613% | 0.15% |
| 12 | FMR LLC | 512K | $267.9M | +16.5% | 2.220% | 0.01% |
| 13 | GEODE CAPITAL MANAGEMENT, LLC | 456K | $238.7M | +0.9% | 1.977% | 0.01% |
| 14 | WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | 341K | $178.3M | -3.9% | 1.477% | 0.59% |
| 15 | Invesco Ltd. | 330K | $172.5M | -9.8% | 1.429% | 0.03% |
| 16 | Polar Capital Holdings Plc | 289K | $151.4M | +7.1% | 1.255% | 0.54% |
| 17 | GOLDMAN SACHS GROUP INC | 277K | $145.2M | -9.3% | 1.203% | 0.02% |
| 18 | ARMISTICE CAPITAL, LLC | 265K | $138.5M | -0.4% | 1.148% | 4.09% |
| 19 | Hood River Capital Management LLC | 250K | $130.6M | +0.8% | 1.082% | 1.31% |
| 20 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 241K | $126.0M | -19.7% | 1.044% | 0.01% |
| 21 | Point72 Asset Management, L.P. | 235K | $123.0M | +71.8% | 1.019% | 0.17% |
| 22 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 217K | $113.4M | -1.1% | 0.940% | 0.02% |
| 23 | MORGAN STANLEY | 191K | $100.1M | +27.1% | 0.830% | 0.01% |
| 24 | BANK OF AMERICA CORP /DE/ | 190K | $99.2M | -54.4% | 0.822% | 0.01% |
| 25 | Pictet Asset Management Holding SA | 187K | $97.9M | +2.9% | 0.812% | 0.10% |
denotes a marquee investor (Buffett, Burry, ARK, Tiger Global, Pershing Square, Baupost and other widely-followed managers). “% of Fund” shows how much of that investor’s total 13F portfolio is invested in MDGL — a direct measure of their conviction.
Filings activity in MDGL during Q1 2026, grouped by how each filer changed its position.
8 quarters of 13F filings · Δ columns show change vs prior quarter
| Quarter | Inst. Holders | Δ Holders | Ownership % | Δ Ownership | Total 13F Value | Δ Value |
|---|---|---|---|---|---|---|
| Q1 2026 | 365 | 4.9% | 110.49% | 12.59 pp | $12.25B | 10% |
| Q4 2025 | 384 | +13% | 123.08% | +25.98 pp | $13.64B | +27% |
| Q3 2025 | 339 | +12% | 97.10% | +33.42 pp | $10.76B | +52% |
| Q2 2025 | 302 | 3.5% | 63.68% | 6.71 pp | $7.06B | 9.5% |
| Q1 2025 | 313 | +13% | 70.39% | +3.53 pp | $7.80B | +5.3% |
| Q4 2024 | 276 | +11% | 66.86% | +24.55 pp | $7.41B | +58% |
| Q3 2024 | 248 | +0.4% | 42.31% | 13.44 pp | $4.69B | 24% |
| Q2 2024 | 247 | — | 55.75% | — | $6.18B | — |
Source: SEC 13F institutional filings. Ownership % requires market cap data and will show once linked. Δ columns compare to the immediately prior filed quarter.
Quick answers to the most common questions about buying MDGL stock.
Based on Q1 2026 13F filings, institutional ownership of Madrigal Pharmaceuticals, Inc. stands at 110.5%, held across 365 reporting institutions.
BAKER BROS. ADVISORS LP is the largest reported institutional holder of MDGL, with approximately 2,141,701 shares worth $1.12B as of Q1 2026.
Yes — 3 widely-followed marquee investors appear among the top 25 institutional holders of MDGL, including CITADEL ADVISORS LLC, SUSQUEHANNA INTERNATIONAL GROUP, LLP, Point72 Asset Management, L.P..
Our composite Smart Money Score for MDGL is 45 out of 100 (Neutral). It combines net institutional buying activity, ownership shift, marquee investor presence, and holder-count growth.
61 institutions opened new positions in MDGL during Q1 2026, while 80 fully exited. 89 added to existing positions and 211 trimmed.
MDGL institutional ownership fell by 12.59 percentage points quarter-over-quarter, with a net change of -19 holders.
The top 10 institutions account for 59.4% of all reported 13F value in MDGL, and the top 25 account for 78.9%.
All data is sourced from SEC Form 13F filings, which institutional investment managers with at least $100M in assets are required to file each quarter. We process every 13F filing from EDGAR and recompute the aggregates after each cycle. Insider transactions are sourced from Form 4 filings.
Madrigal Pharmaceuticals, Inc. (MDGL) Institutional Ownership