Exelixis, Inc. (EXEL) Earnings History
Elite Compounder27 years of earnings data (1999–2025) · 5-year EPS CAGR exceeds 18% — top-tier earnings quality
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Exelixis, Inc. (EXEL) Earnings Overview
As of October 3, 2026, Exelixis, Inc. (EXEL) reported trailing twelve-month net income of $861M, reflecting +58.0% year-over-year growth. The company earned $3.31 per diluted share over the past four quarters, with a net profit margin of 33.7%.
Looking at the long-term picture, EXEL's 5-year EPS compound annual growth rate (CAGR) stands at +51.4%, indicating exceptional earnings growth. The company achieved its highest annual net income of $783M in fiscal 2025, representing a new all-time high.
Exelixis, Inc. maintains industry-leading profitability with a gross margin of 96.4%, operating margin of 37.6%, and net margin of 33.7%. This margin structure demonstrates strong pricing power and operational efficiency. View revenue history →
Compared to peers including INCY ($1.61B net income, 25.0% margin), ALKS ($66M net income, 16.4% margin), JAZZ ($941M net income, -8.3% margin), EXEL has outperformed on profitability metrics. Compare EXEL vs INCY →
EXEL Earnings vs Peers
Earnings metrics vs comparable public companies
EXEL Historical Earnings Data (1999–2025)
27 years| Fiscal Year | Net Income | YoY % | Operating Income | EPS (Diluted) | Net Margin | Op. Margin |
|---|---|---|---|---|---|---|
| 2025 | $783M | +50.1% | $872M | $2.78 | 33.7% | 37.6% |
| 2024 | $521M | +150.9% | $605M | $1.76 | 24.0% | 27.9% |
| 2023 | $208M | +14.0% | $171M | $0.65 | 11.4% | 9.3% |
| 2022 | $182M | -21.1% | $201M | $0.56 | 11.3% | 12.5% |
| 2021 | $231M | +106.7% | $287M | $0.72 | 16.1% | 20.0% |
| 2020 | $112M | -65.2% | $110M | $0.35 | 11.3% | 11.1% |
| 2019 | $321M | -53.5% | $369M | $1.02 | 33.2% | 38.2% |
| 2018 | $690M | +347.4% | $439M | $2.21 | 80.8% | 51.4% |
| 2017 | $154M | +319.6% | $166M | $0.49 | 34.1% | 36.7% |
| 2016 | -$70M | +58.6% | -$28M | $-0.28 | -36.7% | -14.7% |
| 2015 | -$170M | +36.8% | -$121M | $-0.81 | -456.6% | -326.6% |
| 2014 | -$269M | -9.7% | -$224M | $-1.38 | -1069.4% | -893.9% |
| 2013 | -$245M | -65.8% | -$201M | $-1.33 | -781.0% | -640.5% |
| 2012 | -$148M | -295.0% | -$122M | $-0.92 | -311.2% | -258.0% |
| 2011 | $76M | +182.0% | $90M | $0.58 | 26.1% | 30.9% |
| 2010 | -$92M | +31.7% | -$91M | $-0.85 | -49.9% | -49.4% |
| 2009 | -$135M | +17.0% | -$122M | $-1.26 | -89.1% | -80.3% |
| 2008 | -$163M | -88.5% | -$179M | $-1.54 | -138.2% | -152.1% |
| 2007 | -$86M | +14.9% | -$157M | $-0.87 | -76.1% | -138.4% |
| 2006 | -$101M | -20.2% | -$127M | $-1.17 | -102.9% | -128.5% |
| 2005 | -$84M | +38.5% | -$94M | $-1.07 | -111.1% | -123.7% |
| 2004 | -$137M | -44.8% | -$135M | $-1.89 | -259.7% | -255.8% |
| 2003 | -$95M | -10.0% | -$96M | $-1.45 | -183.9% | -186.8% |
| 2002 | -$86M | -21.0% | -$88M | $-1.52 | -194.3% | -198.1% |
| 2001 | -$71M | +5.5% | -$75M | $-1.53 | -173.6% | -183.7% |
| 2000 | -$75M | -302.7% | -$43M | $-2.43 | -304.2% | -173.1% |
| 1999 | -$19M | - | -$19M | $-4.60 | -178.1% | -179.0% |
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EXEL — Frequently Asked Questions
Quick answers to the most common questions about buying EXEL stock.
What is EXEL earnings per share (EPS)?
EXEL trailing twelve-month (TTM) diluted EPS is $3.31, reflecting +58.0% year-over-year growth. The 5-year EPS CAGR is +51.4%. Complete EPS history from 1999 to 2025 is available in the table on this page.
What is Exelixis, Inc.'s net income?
Exelixis, Inc. (EXEL) trailing twelve-month net income is $861M as of 2025. Earnings grew +58.0% year-over-year. Exelixis, Inc. has been profitable for 9 consecutive years.
Is EXEL profitable?
Yes, EXEL is profitable with a TTM net income of $861M and a net profit margin of +33.7%. Exelixis, Inc. has generated profits for 9 consecutive years.
What is EXEL's earnings growth rate?
EXEL compound annual EPS growth rates (CAGR): 1-Year: +58.0%, 3-Year: +70.6%, 5-Year: +51.4%, 10-Year: N/A. These figures measure the annualised rate of diluted EPS growth over each period, based on data from 1999 to 2025.
What are EXEL's profit margins?
Exelixis, Inc. net profit margin is +33.7%, operating margin is +37.6%, and gross margin is +96.4%. Above-average net margins reflect strong pricing power and competitive moat. Return on Equity is +35.5%.
Is EXEL growing earnings?
Yes, EXEL earnings are accelerating — EPS growth of +58.0% exceeds the 5-year CAGR of +51.4%. TTM net income reached $861M. Earnings momentum is strengthening.
What was EXEL's best earnings year?
Exelixis, Inc.'s highest annual net income on record is $783M, achieved in fiscal year 2025. Earnings history on this page spans 1999 to 2025 and includes all annual and quarterly figures.
What were EXEL's earnings last quarter?
EXEL's most recent reported quarter was Q2 2026. Net income was $212M with diluted EPS of $0.82. For a full breakdown of all quarters, see the quarterly earnings table on this page.